“Profil Stabilitas Tetrasiklin”
Tetrasiklin memiliki 3 pKa yaitu :
- pKa 1 : 3,3
- pKa 2 : 7,7
- pKa 3 : 9,5
1. Profil Stabilitas Tetrsiklin pKa :3,3
Rumus yang digunakan :
% terionisasi = 100 ____
1 + antilog (pKa – pH)
pH : 0
% terionisasi = 100 ___
1 + antilog (3,3 – 0)
= 0,050
pH : 1
% terionisasi = 100 ___
1 + antilog (3,3 – 1)
= 0,498
pH : 2
% terionisasi = 100 ___
1 + antilog (3,3 – 2)
= 4,773
pH : 3
% terionisasi = 100 ___
1 + antilog (3,3 – 3)
= 33,386
pH : 4
% terionisasi = 100 ___
1 + antilog (3,3 – 4)
= 83,366
pH : 5
% terionisasi = 100 ___
1 + antilog (3,3 – 5)
= 98,044
pH : 6
% terionisasi = 100 ___
1 + antilog (3,3 – 6)
= 99,800
pH : 7
% terionisasi = 100 ___
1 + antilog (3,3 –7)
= 99,980
pH : 8
% terionisasi = 100 ___
1 + antilog (3,3 – 8)
= 99,998
pH : 9
% terionisasi = 100 ___
1 + antilog (3,3 – 9)
= 99,999
pH : 10
% terionisasi = 100 ____
1 + antilog (3,3 – 10)
= 99,9998
pH : 11
% terionisasi = 100 ____
1 + antilog (3,3 – 11)
= 99,9999
pH : 12
% terionisasi = 100 ____
1 + antilog (3,3 – 12)
= 99,99998
pH : 13
% terionisasi = 100 ____
1 + antilog (3,3 – 13)
= 99,99999
pH : 14
% terionisasi = 100 ____
1 + antilog (3,3 – 14)
= 100
Tabel profil stabilitas tetrasiklin pKa 3,3
| no | pH | % terionisasi |
| 1. | 0 | 0,05 |
| 2. | 1 | 0,498 |
| 3. | 2 | 4,773 |
| 4. | 3 | 33,386 |
| 5. | 4 | 83,366 |
| 6. | 5 | 98,044 |
| no | pH | % terionisasi |
| 7. | 6 | 99,8 |
| 8. | 7 | 99,98 |
| 9. | 8 | 99,998 |
| 10. | 9 | 99,999 |
| 11. | 10 | 99,9998 |
| 12. | 11 | 99,9999 |
| 13. | 12 | 100 |
| 14. | 13 | 100 |
| 15. | 14 | 100 |
Kurva Stabilitas Tetrasiklin pKa 3,3
Rumus yang digunakan :
% terionisasi = 100 ____
1 + antilog (pKa – pH)
pH : 0
% terionisasi = 100 ____
1 + antilog (7,7 – 0)
= 1,99X10-6
pH : 1
% terionisasi = 100 ____
1 + antilog (7,7– 1)
= 1,99X10-5
pH : 2
% terionisasi = 100 ____
1 + antilog (7,7– 2)
= 1,99X10-4
pH : 3
% terionisasi = 100 ____
1 + antilog (7,7– 3)
= 1,99X10-3
pH : 4
% terionisasi = 100 ____
1 + antilog (7,7– 4)
= 1,99X10-2
pH : 5
% terionisasi = 100 ____
1 + antilog (7,7– 5)
= 0,199
pH : 6
% terionisasi = 100 ____
1 + antilog (7,7– 6)
= 1,956
pH : 7
% terionisasi = 100 ____
1 + antilog (7,7– 7)
= 16,634
pH : 8
% terionisasi = 100 ____
1 + antilog (7,7– 8)
= 66,614
pH : 9
% terionisasi = 100 ____
1 + antilog (7,7– 9)
= 95,227
pH : 10
% terionisasi = 100 ____
1 + antilog (7,7– 10)
= 99,501
pH : 11
% terionisasi = 100 ____
1 + antilog (7,7– 11)
= 99,949
pH : 12
% terionisasi = 100 ____
1 + antilog (7,7– 12)
= 99,9995
pH : 13
% terionisasi = 100 ____
1 + antilog (7,7– 13)
= 99,99998
pH : 14
% terionisasi = 100 ____
1 + antilog (7,7– 14)
= 99,99999
Tabel profil stabilitas tetrasiklin pKa 7,7
| no | pH | % terionisasi |
| 1. | 0 | 1,99X10-6 |
| 2. | 1 | 1,99X10-5 |
| 3. | 2 | 1,99X10-4 |
| 4. | 3 | 1,99X10-3 |
| 5. | 4 | 1,99X10-2 |
| 6. | 5 | 0,199 |
| 7. | 6 | 1,956 |
| 8. | 7 | 16,634 |
| 9. | 8 | 66,614 |
| 10. | 9 | 95,227 |
| 11. | 10 | 99,501 |
| 12. | 11 | 99,949 |
| 13. | 12 | 99,9995 |
| 14. | 13 | 99,99998 |
| 15. | 14 | 99,99999 |
Kurva Stabilitas Tetrasiklin pKa 7,7
3. Profil Stabilitas Tetrsiklin pKa :9,5
Rumus yang digunakan :
% terionisasi = 100 ____
1 + antilog (pKa – pH)
pH : 0
% terionisasi = 100 ____
1 + antilog (9,5 – 0)
= 3,16X10-8
pH : 1
% terionisasi = 100 ____
1 + antilog (9,5– 1)
= 3,16X10-7
pH : 2
% terionisasi = 100 ____
1 + antilog (9,5– 2)
= 3,16X10-6
pH : 3
% terionisasi = 100 ____
1 + antilog (9,5– 3)
= 3,16X10-5
pH : 4
% terionisasi = 100 ____
1 + antilog (9,5– 4)
= 3,16X10-4
pH : 5
% terionisasi = 100 ____
1 + antilog (9,5– 5)
= 3,16X10-3
pH : 6
% terionisasi = 100 ____
1 + antilog (9,5– 6)
= 3,16X10-2
pH : 7
% terionisasi = 100 ____
1 + antilog (9,5– 7)
= 0,316
pH : 8
% terionisasi = 100 ____
1 + antilog (9,5– 8)
= 3,065
pH : 9
% terionisasi = 100 ____
1 + antilog (9,5– 9)
= 24,026
pH : 10
% terionisasi = 100 ____
1 + antilog (9,5– 10)
= 75,975
pH : 11
% terionisasi = 100 ____
1 + antilog (9,5– 11)
= 96,936
pH : 12
% terionisasi = 100 ____
1 + antilog (9,5– 12)
= 99,687
pH : 13
% terionisasi = 100 ____
1 + antilog (9,5– 13)
= 99,946
pH : 14
% terionisasi = 100 ____
1 + antilog (9,5– 14)
= 99,999
Tabel profil stabilitas tetrasiklin pKa 9,5
| no | pH | % terionisasi |
| 1. | 0 | 3,16X10-8 |
| 2. | 1 | 3,16X10-7 |
| 3. | 2 | 3,16X10-6 |
| 4. | 3 | 3,16X10-5 |
| 5. | 4 | 3,16X10-4 |
| 6. | 5 | 3,16X10-3 |
| 7. | 6 | 3,16X10-2 |
| 8. | 7 | 0,316 |
| 9. | 8 | 3,065 |
| 10. | 9 | 24,026 |
| 11. | 10 | 75,975 |
| 12. | 11 | 96,936 |
| 13. | 12 | 99,687 |
| 14. | 13 | 99,946 |
| 15. | 14 | 99,999 |
Kurva Stabilitas Tetrasiklin pKa 9,5
